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orthopoxvirus variola It has been previously confirmed that
2018-11-08
It has been previously confirmed that SB-505124 selectively inhibits TGF-β and activin signaling more efficiently than its analog SB-431542 (DaCosta Byfield et al., 2004), which has been shown to induce neural differentiation when used in combination with Noggin (Chambers et al., 2009). IWP-2, on th
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Pluripotent stem cells such as embryonic stem cells
2018-11-08
Pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have special abilities to differentiate into cells of all three germ layers (pluripotency) and to undergo unlimited proliferation while retaining their identities (self-renewal) (Nichols and Smith
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In this study we first demonstrated that the CD
2018-11-08
In this study, we first demonstrated that the CD44+ population isolated from the HCT-15 human colon cancer cell line not only exhibited multiple in vitro features of CSCs but also showed higher in vivo tumorigenicity. In accordance, knocking down CD44 expression in HCT-15 bosentan resulted in reduc
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br Source of funding This work
2018-11-08
Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures
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In the present study our data generated
2018-11-08
In the present study, our data generated from the biochemical assays (Fig. 7) and functional studies (Figs. 2–5) indicated that the C-terminal PDZ motif of CXCR2 is important for EPC motility and angiogenic activity both in vitro and in vivo. Our findings suggested that a PDZ-based CXCR2 macromolecu
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We identified a number of CD markers that are expressed
2018-11-08
We identified a number of CD markers that are expressed in both osteoprogenitor and adipoprogenitor Etonogestrel and thus can be employed as core markers of the BMSCs phenotype. Our data corroborate previous studies that employed alternative technologies to identify markers for multipotent BMSCs. C
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Urine of the patient was collected
2018-11-08
Urine of the patient was collected for tubulin isolation and expansion. The urine cells were tested for free of mycoplasma. For reprogramming, the urine cells were transfected with episomal plasmids expressing Oct4, Sox2, Klf4 and miR-302-367 cluster. About 3weeks after transfection, many colonies w
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With these results we provide evidence that
2018-11-08
With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro
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By studying the relationships of these subpopulations to
2018-11-08
By studying the relationships of these subpopulations to each other, it was found that GMPs are able to create neutrophils but unexpectedly lack the potential to form eosinophils and basophils. Furthermore, and against the prevailing assumption, the GMPs were found to be derivatives of the same bran
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Herein we observed increased SEMA A gene
2018-11-08
Herein, we observed increased SEMA3A gene expression in BMSCs of all patients compared to the control group. In the literature, we found two studies of SEMA3A in AML: The first reported that epigenetic changes increases SEMA3A expression and contributes to EZH2 silencing in patients with secondary A
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The approach for stem cell identification utilized herein is
2018-11-08
The approach for stem cell identification utilized herein is functional, based on the relative quiescence and thus label retention property of stem buy BMS-907351 within a mixed epithelial population. Long-term 5-bromo-2′-deoxyuridine (BrdU) retention has been previously used to label stem cells in
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Whereas we found that Blimp
2018-11-08
Whereas we found that Blimp-1 deletion induced pluripotency in PGCs, the effects of Blimp-1 overexpression in pluripotent order Staurosporine appear to be more complicated. Forced expression of Blimp-1 in ESCs induces growth retardation (Nagamatsu et al., 2011). During PGC induction from ESCs, indu
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To address whether the bivalent state
2018-11-08
To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus
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br Experimental Procedures br Author Contributions
2018-11-07
Experimental Procedures Author Contributions Acknowledgments This work was supported by grants to W.H. from the National Natural Science Foundation of China (81372258, 81572827), the Major State Basic Research Development Program of China (2013CB910802), and the Program for Professor of Spe
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br Methods br Results br Discussion Mean birth weight
2018-11-07
Methods Results Discussion Mean birth weight was significantly higher among midwifery patients, in every moderate quality study in which it was examined (Heins et al., 1990; McLaughlin et al., 1992; Visintainer et al., 2000). Other studies have reported a birth weight gradient associated wi
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