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In addition we observed significantly elevated levels
2018-11-02
In addition, we observed significantly elevated levels of synapsin and dopamine in Parkin cultures, although the changes in PINK1 cells did not reach statistical significance when compared with control iPSC- or ESC-derived floor-plate mDA neurons. Increased DA levels may appear, in contrast to the w
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br Results br Discussion We generated a
2018-11-02
Results Discussion We generated a library of iPSCs from patients with sickle cell anemia of diverse ethnicities and HBB haplotypes to study the biology of these ras pathway and the feasibility of their generation from blood samples collected from patients in distant locations and shipped froz
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Here using hNPCs derived from RTT patient iPSCs as
2018-11-02
Here, using hNPCs derived from RTT patient iPSCs as an example, we have shown that our method of hypoxia-mediated rapid astrocytic differentiation of hNPCs can be applied to functional analysis of patient-derived astrocytes. We revealed that MECP2 MT astrocytes diminish the soma size, neurite outgro
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hcv virus The structure of La SrMnO LSMO x is
2018-11-02
The structure of La1–SrMnO3 (LSMO-x) is far from cubic perovskite. According to Ref. [7], this structure has two types of distortions, which are caused by either the mismatch between the size of the cations and the size of the corresponding free space (type 1), or by the Jahn–Teller (JT) effect (typ
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The mixture of pure nanoparticles of the
2018-11-02
The mixture of pure nanoparticles of the influenza virus (strain A1-H1N1) and albumin proteins (as an example of impurity) can be considered as a model of dispersions in the technological process of vaccine production. The influenza virus particle was approximated as a homogeneous sphere with the me
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To determine whether economic psychological and
2018-11-02
To determine whether economic, psychological, and neighborhood indices explain excess risk by race/ethnicity in high AL, we fit a series of linear regression models, with results displayed in Tables 3 and 4. We focused on the proportion of excess risk in high AL by race/ethnicity that was explained
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Risk behaviours are important threats during
2018-11-01
Risk behaviours are important threats during adolescence due to possible lifetime negative consequences. Their prevalence is high in the USA: the percentage of those who ever smoke, drunk, use marijuana and cocaine was respectively 44.7, 70.6, 39.9 and 18.2% in a national survey; the percentages of
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Advancement in diagnostic capabilities is an
2018-11-01
Advancement in diagnostic capabilities is an important step to improving outcomes of trauma-related infections. Rapid diagnosis, treatment, and control of bacterial infections are necessary to reduce morbidity and mortality. Raman spectroscopy combined with nanotechnology is a potential platform upo
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Fomentar el deporte femenino es ingrediente vital
2018-11-01
Fomentar el deporte femenino es ingrediente vital en el intento de alcanzar hábitos de vida saludables. La unesco, subraya los efectos positivos de la actividad física en la vida de los ciudadanos: reducción de los riesgos de padecer enfermedades crónico degenerativas, ampliación de la esperanza de
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Compared to the exposure to the external environment whether
2018-11-01
Compared to the exposure to the external environment, whether and how the internal endocrine environment can illicit intergenerational effects is less understood. Hyperandrogenism is a common endocrine disorder that happens in 5–10% of reproductive-aged women. Previous animal studies suggest that in
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br Beyond extinction cognitive forms
2018-11-01
Beyond extinction: cognitive forms of fear regulation While the efficacy of exposure-based CBT depends on the ability of a given individual to acquire and retrieve extinction memories (Berry et al., 2009), cognitive strategies can also be employed to regulate conditioned fear responding. Standard
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useful site The present study examines age
2018-11-01
The present study examines age-related differences in ventral striatal (VS) iFC and dorsal striatal (DS) iFC. This approach permits us to define and contrast the VS iFC and DS iFC networks, which are broadly linked to motivation and cognitive function, respectively (Haber, 2003), and to examine the
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Instead we cautiously speculate that our results may be
2018-11-01
Instead, we cautiously speculate that our results may be attributable to the fact that the impact of tobacco alone on adolescent neural responses may differ from the impact of tobacco in combination with other substances. In line with prior work in this area, the use of multiple substances in synerg
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Although our results imply sensorimotor system involvement
2018-11-01
Although our results imply sensorimotor system involvement in facial expression processing, they do not give any indication of whether children explicitly recognized the expressions they observed. Explicit and implicit recognition of facial expressions are thought to be distinct processes (Mathersul
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We also showed that higher ReHo in
2018-11-01
We also showed that higher ReHo in left middle frontal gyrus was associated with poorer cognitive control ability. Children who showed increased homogeneity in left middle frontal gyrus during rest took longer to switch from a rule they learned previously. Lesions to the prefrontal BV6 selectively
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