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To address whether the bivalent state
2018-11-08
To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus
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br Experimental Procedures br Author Contributions
2018-11-07
Experimental Procedures Author Contributions Acknowledgments This work was supported by grants to W.H. from the National Natural Science Foundation of China (81372258, 81572827), the Major State Basic Research Development Program of China (2013CB910802), and the Program for Professor of Spe
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br Methods br Results br Discussion Mean birth weight
2018-11-07
Methods Results Discussion Mean birth weight was significantly higher among midwifery patients, in every moderate quality study in which it was examined (Heins et al., 1990; McLaughlin et al., 1992; Visintainer et al., 2000). Other studies have reported a birth weight gradient associated wi
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br Introduction In order to obtain easy access
2018-11-07
Introduction In order to obtain easy access to accurate material and order LY2606368 inventory data for the modelling of industrial bioprocesses at the early stages of process design, a Microsoft® Excel model has been developed, termed the CeBER Bioprocess Modeller (Centre for Bioprocess Engineer
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br Principle of operation The feed is
2018-11-07
Principle of operation The feed, is dissolved in the recovered solvent P with the addition of a small amount of fresh solvent P (Fig. 1). The amount of P depends on the loss of solvent with concentrated solution W. Energy required for dissolution in the process can be supplied by solvent P coming
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From economical viewpoint taking f as a production cost
2018-11-07
From economical viewpoint, taking f as a production cost, as a production supply and as a vector price. Here, conjugate function f* represent maximum profile in the production. Unfortunately, these economical interpretations hold when f is convex and lower semi continuous, because defined by is the
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Runsinarith found significant impacts of mobile telephones e
2018-11-07
Runsinarith (2008) found significant impacts of mobile telephones, electricity, irrigation and roads on poverty incidence through the application of quantile regressions in Cambodia for the year 2006. He concluded that mobile technology was the infrastructure with the highest impact on poverty reduc
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br Resumo br Resumo br Resumo br Resumo
2018-11-07
Resumo Resumo Resumo Resumo Resumo Resumo INTRODUÇÃO E OBJETIVOS No Brasil, há predominância do transporte rodoviário, sendo o mesmo responsável pela movimentação de bilhões de reais. Dessa forma, caspofungin qualidade do sono é de extrema importância para motoristas, ainda mais aq
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Doxorubicin DOXO a member of the
2018-11-07
Doxorubicin (DOXO), a member of the antineoplastic antibiotic family of anthracyclines, is a chemotherapeutic agent developed in the 1960s [5], that is still widely used in the treatment of a variety of malignancies, such as acute leukemia, non-Hodgkin lymphomas, breast cancer, Hodgkin\'s disease, a
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Several clinical and epidemiological studies have establishe
2018-11-07
Several clinical and epidemiological studies have established cardiovascular risk factors (including smoking, hypertension, and serum lipid status) to be associated with AMD development and progression, and both diseases share susceptibility genes (Miller, 2013; Yip et al., 2015; Tomany et al., 2004
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Remarkably Cornelius et al report for the first time
2018-11-07
Remarkably, Cornelius et al. report for the first time HBV-neutralizing antibodies in all seven so-far tested human recipients of the BM32 vaccine, i.e., of preS antigen without other HBV antigens. Assay of neutralizing antibodies has been difficult because for long time the only HBV-susceptible cel
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Although HCV RNA and genotype testing rates have
2018-11-07
Although, HCV RNA and (RS)-CPP testing rates have improved in recent years and are similar to those reported for HCV positive Veterans and Kaiser Permanente members in the United States (95%) and higher than for primary care in Canada and United States (47.0% to 60.9%), there is a further need to re
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To determine if the overexpression of miR
2018-11-07
To determine if the overexpression of miR-137 negatively regulate EFNB2 expression, human neuroblastoma SH-SY5Y cells were transfected with mature miR-137 sequences or negative control miRNAs. The results showed that the overexpression of miR-137 did not affect the mRNA expression of EFNB2 but signi
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br Conflicts of Interest br Author Contributions Z
2018-11-07
Conflicts of Interest Author Contributions Z.H.X. and Z.C. designed experiments and co-wrote the manuscript. Z.H.X. and Y.W. performed most of the experiment, acquired most of the data presented, and performed the statistical analyses. B.C., W.W.H., and Z.X.N. performed in imaging. C.L.X., and
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In spite of these interesting observations some additional q
2018-11-07
In spite of these interesting observations, some additional questions arise from the study. For example, consistent with previous reports, circadian phase and period length are influenced by diet (). However, here the HFD has the general effect in WT mice of shortening period length rather than leng
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