• The tripartite motif containing TRIM

  2019-04-26

  

  The tripartite motif-containing (TRIM) proteins contain a RING domain, which is most commonly used to polyubiquitinate target proteins for proteasome-dependent degradation [9]. Accumulated evidence pointed to the involvement of TRIM proteins in the development, progression or metastasis of cancers [

• The overall MSTS score in our study was The MSTS

  2019-04-26

  

  The overall MSTS score in our study was 97.3%. The MSTS score after curettage treatment was 99%, better than that in previous studies, which ranged from 90% to 93%. Two cohort studies showed higher MSTS scores for patients who underwent intralesional curettage than those who underwent wide resection

• pde3 In this study the distribution

  2019-04-26

  

  In this study, the distribution of LPs was also analyzed. Similar to previously published data, there was a tendency that vLPs were more frequently observed in patients with ICM than in patients with NICM. However, the total number of those abnormal ventricular electrograms was less documented than

• However she had an attack on

  2019-04-26

  

  However, she had an attack on Day 7. The ECG monitor was normal until 4:25 AM (Fig. 1a). ST segment elevation was evident, and the patient experienced chest pain at 4:30 AM (Fig. 1b). ST segment elevations were seen in leads II, III, and aVF on the 12-lead ECG. As sublingual nitroglycerin was ineffe

• BMN673 br Discussion The cardiac manifestations of organopho

  2019-04-26

  

  Discussion The cardiac manifestations of organophosphorus poisoning are well known, involving various electrocardiographic abnormalities that may range from sinus tachycardia to ST elevation. Such most common abnormalities are sinus bradycardia, prolonged QT interval, and ST elevation [2–4]. Most

• br Discussion Digoxin has multiple effects on the myocardium

  2019-04-26

  

  Discussion Digoxin has multiple effects on the myocardium and has multiple cardiac-related uses. In the treatment of atrial fibrillation, digoxin increases vagal tone to prolong the refractory haspin inhibitor at the AV node, decreasing ventricular response to higher atrial rates [3]. Toxic dose

• In the largest published case series Rossi et

  2019-04-26

  

  In the largest published case series, Rossi et al. identified seven cases of infant B-ALL, including three cases of congenital leukemia, with lineage switch from B-lymphoid to myelomonocytic leukemia [12]. An additional two cases were described with a switch from AML M5 to B-ALL. Of the nine describ

• Many studies over the past years have shown the

  2019-04-26

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. Th

• br Conclusions br Disclosures br Funding Sources br Introduc

  2019-04-26

  

  Conclusions Disclosures Funding Sources Introduction Pulmonary vein isolation (PVI) has become an accepted treatment for atrial fibrillation (AF) [1]. The efficacy of PVI is sometimes insufficient, and atrial substrate modification of target specific AF signals indicating the substrate r

• Our patient a year old woman

  2019-04-25

  

  Our patient (a 24-year-old woman) arrived in Italy from Eastern Europe in March 2013 as an illegal immigrant. Three months later she was admitted to our hospital. Her blood counts were as follows: leukocytes 410.7×109/L, platelets 391×109/L, Hb 11g/dl, with immature myeloid tyrosol at differential c

• (S)-Crizotinib br Mega cohort studies Remote monitoring coll

  2019-04-25

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• Since antithrombotic therapy for patients with AF is rapidly

  2019-04-25

  

  Since antithrombotic therapy for patients with AF is rapidly changing with the increasing use of dabigatran, rivaroxaban, and apixaban, some of the primary issues that will influence the future revision of various guidelines (HRS [Heart Rhythm Society], ESC [European Society of Cardiology], ACC [Ame

• br Methods br Results br Discussion br Conclusions

  2019-04-25

  

  Methods Results Discussion Conclusions Conflict of interest Acknowledgments We thank Mr. John Martin for his linguistic assistance, and Mr. Jiro Suto for technical assistance in developing the QRS-T subtraction program. This study was supported by the Fukuda Foundation for Medical

• All these receptors tightly control tissue

  2019-04-25

  

  All these receptors tightly control tissue homeostasis, and any dysregulation of these ligand–receptor systems (mutations, overexpression, etc.) disturbs cell communication and leads to pathological situations. Bone formation and bone remodelling are then controlled by a large panel of cytokines and

• The GCT usually involves a cladding that consisted

  2019-04-25

  

  The GCT usually involves a cladding that consisted of reactive bone and fibrosis, with a distinct boundary surrounded by soft tissue. Nevertheless, the active cladding is very thin among patients with severe invasiveness, including tumors that extend directly in into the muscle and fat, or other sig

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