• Taken together our findings support the hypothesis

  2018-10-20

  

  Taken together, our findings support the hypothesis that AM can rescue OPC differentiation via receptor-mediated Akt signaling. However, there are some important caveats to keep in mind. First, our current study used only a pure cell culture system. However, to prove clinically-relevant supportive/p

• We also observed the alteration of

  2018-10-20

  

  We also observed the alteration of proteomic networks related to the apoptotic and proliferative pathways. Senescence and apoptosis are essential mechanisms for ionomycin to respond to the changing environment. Apoptosis involves intricate proteomic networks and Table 7 of S1 in Ref. Mindaye et al.

• In addition to supplying a source of growth factors

  2018-10-20

  

  In addition to supplying a source of growth factors and signaling molecules, blood vessels also provide a physical framework that can support the migration of neural progenitors during development and in the adult calcium channels (Whitman et al., 2009). In the embryonic and adult rodent SVZ, newly

• br Funding This work was supported

  2018-10-20

  

  Funding This work was supported by Department of Neurosurgery, the University of Texas Health Science Center at Houston, Memorial Hermann Foundation-Staman Ogilvie Fund, the Bentsen Stroke Center, the TIRR Foundation through Mission Connect (No. 014-115), Craig H. Neilsen Foundation (No. 338617),

• Previously we showed that the

  2018-10-20

  

  Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

• pten pathway We also found clear differences in the

  2018-10-20

  

  We also found clear differences in the amount of stress fibers between the perivascular derivatives. Abundant stress fibers were found in con-vSMCs located throughout the entire cell body. While hiPSC syn-vSMCs had fewer stress fibers, pericyte derivatives demonstrated the lowest levels of stress fi

• Previously we showed that the

  2018-10-20

  

  Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

• Unlike these previous methods the

  2018-10-20

  

  Unlike these previous methods, the 3S reprogramming system generates partially reprogrammed iPSCs in a reproducible and predictable manner by regulating the amount of KLF4. These orexin a resume reprogramming upon increased KLF4 expression and therefore are not aberrantly reprogrammed but have paus

• Here we propose a hypothesis that explains

  2018-10-20

  

  Here, we propose a hypothesis that explains how a mild MIR can contribute to azidothymidine overgrowth by enhancing neural stem and progenitor cell proliferation through the dysregulation of cellular redox signaling. This hypothesis is based on evidence that reactive oxygen species (ROS) at nontoxi

• Taken together our results demonstrate an essential role for

  2018-10-20

  

  Taken together, our results demonstrate an essential role for STAT5 in the regulation of adult IESC homeostasis and response to intestinal injury and regeneration. Functionally, genetic activation of Stat5 increases IESC regeneration to replenish injured intestinal epithelia, conferring resistance t

• am580 The seemingly shared ability of independently evolved

  2018-10-20

  

  The seemingly shared ability of independently evolved (Extavour and Akam, 2003; Ewen-Campen et al., 2010) maternal germ plasm regulators to engage multiple proteins and RNA partners provide new insight and testable models for mechanisms by which germ plasm assembly, mitochondrial recruitment and Bal

• Renal capsule implantation of Lgr cells further supported

  2018-10-20

  

  Renal troglitazone implantation of Lgr5+ cells further supported the high repopulation capacity of single Lgr5+ cells within the regressed prostate. A limiting-dilution analysis indicated that every prostatic Lgr5+ cell could be a stem cell in regressed prostates, meaning that both luminal and basal

• It should be noted that the apparently inconsistent results

  2018-10-20

  

  It should be noted that the apparently inconsistent results regarding the CD146 status of human ASCs, which were obtained in several studies (Bourin et al., 2013) could at least in part be explained with transitory cells of different sizes, which contain different CD146 protein levels, and with matu

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri

• muscle metabolism The first consistency check we performed w

  2018-10-20

  

  The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

15543 records 1036/1037 page Previous Next First page 上5页 10361037