• Surgery and targeted molecular therapy

  2018-10-22

  

  Surgery and targeted molecular therapy are the two gold standards for GISTs. Surgery is the first choice if a complete resection is possible. Imatinib is indicated for treating patients with KIT-positive (i.e., CD117-positive) unresectable and/or metastatic GISTs. For KIT-mutant proteins, imatinib i

• Arachnoid thickening as a possible

  2018-10-22

  

  Arachnoid thickening as a possible factor for typical TN has seldom been reported. We observed two cases (7.7%) of arachnoid thickening that appeared to be associated with neuralgia development. After adhesiolysis, the immediate postoperative outcome was excellent and good in the two cases. Ishikawa

• br Materials and methods br Results

  2018-10-22

  

  Materials and methods Results and discussion The dose-dependent inhibition of HMG-CoA reductase activity by the extracts as presented in Fig. 1 and the IC50 values in Table 1 showed that there was no significant (P>0.05) difference in the inhibitory abilities of the two extracts. The control o

• A study by Hu et al examined the

  2018-10-22

  

  A study by Hu et al. [59] examined the effects of combined fucoxanthin and conjugated linoleic eukaryotic initiation factor on high-fat diet-induced obesity in rats. The animals were fed a high-fat diet (control), supplemented with two doses of fucoxanthin or low-dose fucoxanthin plus conjugated lin

• We next aimed to test the differentiation capabilities

  2018-10-22

  

  We next aimed to test the differentiation capabilities of the EZ spheres. We found that at any passage for all cell lines regardless of cryopreservation, EZ spheres can be placed in specific neural induction media for terminal neuronal or glial cell differentiation using protocols adapted from those

• br Results br Discussion Controlling the chromosome

  2018-10-22

  

  Results Discussion Controlling the chromosome stability of hESCs and their derivatives remains a fundamental challenge in trials of hESC derivative-based cell therapy. In 2004, Andrew and co-workers reported that chromosomal instability during extensive hESC expansion was due to the monensin

• In summary our work is an important step to

  2018-10-22

  

  In summary, our work is an important step to understand and to control phosphorylation dynamics in human pluripotent stem cell maintenance and differentiation. This is the first report that provides a detailed analysis of MAPKs regulation in hESC in response to a small molecule inhibitor. We have sh

• Thus it is worth mentioning

  2018-10-22

  

  Thus, it is worth mentioning that none of these aforementioned studies undoubtedly provide a definitive answer concerning the potential origin of HSCs in the mouse embryo. To add to the complexity, it is possible, as shown in the Xenopus embryo (Turpen et al., 1997) and suggested in mouse (Matsuoka

• The use of a novel Pax

  2018-10-22

  

  The use of a novel Pax9Venus reporter PSC line allowed the purification of PSC-derived Pax9+ AFE for molecular analysis and enabled the comparison to embryonic Pax9+ AFE. The expression of several pharyngeal endoderm transcription factors in PSC-derived Pax9+ AFE suggests that these Cy3.5 hydrazide

• br Experimental Procedures Briefly hiPSCs were generated fro

  2018-10-22

  

  Experimental Procedures Briefly, hiPSCs were generated from IMR90, CCD-1097SK, BJ1, and NPC cells derived from 11-week-old fetal brain using retroviral expression of OCT4, SOX2, KLF4, and c-MYC or OCT4, NANOG, KLF4, and LIN-28. This study of hESCs and hiPSCs was approved by the UCLA Embryonic Ste

• br Results br Discussion FXR was initially shown to regulate

  2018-10-22

  

  Results Discussion FXRα was initially shown to regulate the enterohepatic cycle and BA biosynthesis. In recent decades, many studies have demonstrated its involvement in other physiological functions (digestion, immunity) and diseases such as diabetes and cancer. FXRα participates in the homeo

• This finding is consistent with our observations

  2018-10-22

  

  This finding is consistent with our observations in human fetal RG cells (Mo and Zecevic, 2008), indicating that in both cell populations Pax6 affects proliferation as well as neuronal fate. Numerous studies have reported the successful transplantation of hESC into rodent brains (Kelly et al., 2004

• Netrin G NTNG part of the netrin DCC neogenin pathway

  2018-10-22

  

  Netrin-G1 (NTNG1; +2.2), part of the netrin/DCC/neogenin pathway, not only is an attractive guidance molecule for enteric neurons (Jiang et al., 2003), but also is involved in the outgrowth of thalamocortical neurons (Lin et al., 2003). Mutations in netrin-G1 are uncommon causes of the Rett syndrome

• br Materials and methods br Results br Discussion The

  2018-10-20

  

  Materials and methods Results Discussion The robust expression and purification of stable and biologically active eukaryotic proteins represent a bottleneck of protein transduction technology (Pan et al., 2010; Patsch & Edenhofer, 2007; Yang et al., 2011). In this study, we demonstrate reco

• cetp inhibitors br Introduction Previously it was thought th

  2018-10-20

  

  Introduction Previously, it was thought that the fully developed mammalian central nervous system (CNS) lacks significant regenerative capacity (Ramon, 1928). However, the recent discovery of neural progenitor cells, including neural stem cetp inhibitors (NSCs), has shown a potential for overcom

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