Previously we showed that the

2018-10-20

Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

Unlike these previous methods the

2018-10-20

Unlike these previous methods, the 3S reprogramming system generates partially reprogrammed iPSCs in a reproducible and predictable manner by regulating the amount of KLF4. These orexin a resume reprogramming upon increased KLF4 expression and therefore are not aberrantly reprogrammed but have paus

Here we propose a hypothesis that explains

2018-10-20

Here, we propose a hypothesis that explains how a mild MIR can contribute to azidothymidine overgrowth by enhancing neural stem and progenitor cell proliferation through the dysregulation of cellular redox signaling. This hypothesis is based on evidence that reactive oxygen species (ROS) at nontoxi

Taken together our results demonstrate an essential role for

2018-10-20

Taken together, our results demonstrate an essential role for STAT5 in the regulation of adult IESC homeostasis and response to intestinal injury and regeneration. Functionally, genetic activation of Stat5 increases IESC regeneration to replenish injured intestinal epithelia, conferring resistance t

am580 The seemingly shared ability of independently evolved

2018-10-20

The seemingly shared ability of independently evolved (Extavour and Akam, 2003; Ewen-Campen et al., 2010) maternal germ plasm regulators to engage multiple proteins and RNA partners provide new insight and testable models for mechanisms by which germ plasm assembly, mitochondrial recruitment and Bal

Renal capsule implantation of Lgr cells further supported

2018-10-20

Renal troglitazone implantation of Lgr5+ cells further supported the high repopulation capacity of single Lgr5+ cells within the regressed prostate. A limiting-dilution analysis indicated that every prostatic Lgr5+ cell could be a stem cell in regressed prostates, meaning that both luminal and basal

It should be noted that the apparently inconsistent results

2018-10-20

It should be noted that the apparently inconsistent results regarding the CD146 status of human ASCs, which were obtained in several studies (Bourin et al., 2013) could at least in part be explained with transitory cells of different sizes, which contain different CD146 protein levels, and with matu

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri

muscle metabolism The first consistency check we performed w

2018-10-20

The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

Neuroanatomical studies indicate that DARPP neurons could be

2018-10-20

Neuroanatomical studies indicate that DARPP32+ neurons could be divided into two populations: one that constructs a direct pathway and another that constructs an indirect pathway. DARPP32+ neurons in the direct pathway express DRD1 and are located in the striosome. On the other hand, those in the in

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments This work is funded by the Canadian Institutes of Health Research (CIHR) (P.W.Z). E.J.P.N. is supported by a CIHR Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award. P.W.Z. is the Canada Research Chair

Hello world!

2018-07-29