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It is important to note that
2020-07-27
It is important to note that some cord blood samples in vaginal and C-section deliveries show very low cytokine expression. However, more vaginal cord blood samples showed increased glycosylase inhibitor of IL-6 and IL-8 whereas more C-section cord blood samples show increased TNF-a and G-CSF expre
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br Conclusion The results of the present study demonstrate t
2020-07-27
Conclusion The results of the present study demonstrate that cysteinyl leukotrienes LTC4, LTD4 and LTE4 cause moderate to marked whereas the dihydroxy leukotriene LTB4 causes small muscle contraction in the stomach in vitro. The LTD4-induced contraction is mediated by CysLT1 in fundus but by CysL
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On the other hand the IL promoter activity induced by
2020-07-27
On the other hand, the IL-8 promoter activity induced by the signalling cascade of the CysLT1-G300S receptor is higher than that of the WT receptor. The chemokine IL-8 is mainly involved in the recruitment and activation of neutrophils and we have previously shown that this chemokine gene is a targe
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Due to intense biological alterations induced by various ris
2020-07-27
Due to intense biological alterations induced by various risk factors of obesity, the adipose tissue undergoes adaptations such as adipocyte hypertrophy superimposed with hyperplasia (Jo et al., 2009). In addition to these changes, the adipocytes experience a process of cellular differentiation ther
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The characteristics and consistencies of sputum
2020-07-27
The characteristics and consistencies of sputum that have been adjudged to be a non-invasive alternative to bronchoscopy and BAL in the diagnosis of respiratory infections were studied in this audit. The sputum classification adopted by the MRCM was easier to assess and evaluate than the previous Ge
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Mono and bi ubiquitination of two
2020-07-26
Mono- and bi-ubiquitination of two lysines, namely K70 and K76, in a small fraction of p33 replication co-factor has been demonstrated in yeast (Barajas and Nagy, 2010, Li et al., 2008). Because mutations of these lysines reduced TBSV repRNA replication in yeast and affected the ability of p33 to in
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CAA is a carcinogenic metabolite of
2020-07-25
CAA is a carcinogenic metabolite of vinyl chloride, forming several different DNA adducts including the cyclic Vinorelbine adducts 3,N4-ethenocytosine (εC), 1,N6-ethenoadenine (εA), N2,3-ethenoguanine (εG), and 1,N2-ethenoguanine (1,N2-εG), with the A and C cyclic adducts the most predominant, and
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Chemokines act as ligands for
2020-07-25
Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation. Human neutrophils express both CXCR-1 and CXCR
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br Discussion The membrane PVase activity components were
2020-07-25
Discussion The membrane PVase activity components were discriminated in this work by pre-incubating with PMSF, mipafox, paraoxon or PMSF + mipafox to irreversibly inhibitPVase activity to discriminate the enzymatic components, (EPα, EPβ, EPγ and EPδ). The concentrations employed to discriminate t
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As the primary model we selected
2020-07-25
As the primary model we selected LDL-receptor knockout mice because these resemble the human plasma lipoprotein profile more closely. Currently, genetic models with reduced milk cholesterol content, which mimic cholesterol-free formula feeding, are unavailable. Thus, instead of modifying milk choles
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We experienced difficulties in observing maturation of
2020-07-25
We experienced difficulties in observing maturation of hESC retinas in rd1 mice even with immunosuppression, but with NOG-rd1-2J mice the transplanted hESC retinas consistently developed mature ONL with rod and cone opsins. Furthermore, graft photoreceptors show signs of developing IS/OS structures
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In the present study we investigated
2020-07-25
In the present study, we investigated the role of EP1R after ICH and its mechanism of action. We hypothesized that EP1R activation aggravates ICH injury but that its blockade reduces injury through the Src kinases and the MMP-9 signaling pathway. To test this hypothesis, we examined the effects of s
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br Materials and methods br
2020-07-25
Materials and methods Results and discussion Conclusions Acknowledgements This work was supported financially by the LIAONING S&T Project (No. 20180550107) and Basic Scientific Research Funds of DLNU (0918110143). Introduction Since 1970s, numerous artificial mimetic enzymes have bee
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Compound was synthesized by the directed metallation procedu
2020-07-25
Compound () was synthesized by the directed -metallation procedure (DOM) at the stage of the amide using butyl lithium and dry ice as CO source for the introduction of the carboxylic group. Thiophene amides were prepared from commercial 3-thiophenecarboxylic moclobemide synthesis by conversion in
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Collectively the results presented here provide new insights
2020-07-25
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of
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