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Finally we have determined for the
2020-09-24
Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent 5-Hydroxy-CTP receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al.,
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br Materials and methods br Results br
2020-09-23
Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor 5 aza 2 deoxycytidine recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial carcinoids c
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Our observation that nuclear but not cytoplasmic EP expressi
2020-09-23
Our observation that nuclear, but not cytoplasmic EP4 expression is associated with different outcomes is interesting. In breast cancer, using the same methods, we did not detect EP4 in the nucleus of malignant orexin antagonist whereas cytoplasmic EP4 was commonly observed [13]. While G protein-cou
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From these and other studies it is
2020-09-23
From these and other studies, it is clear that acriflavine is an interesting PF 04418948 with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for cancer tre
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Cy5 NHS ester (non-sulfonated) receptor In contrast to SQLE
2020-09-23
In contrast to SQLE, HMGCR could be efficiently degraded in Cy5 NHS ester (non-sulfonated) receptor lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is
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Immunofluorescence assays were performed to localize the enz
2020-09-23
Immunofluorescence assays were performed to localize the enzyme during growth and differentiation to further characterize Giardia E1. As stated before, the assays showed that the Cy5 NHS ester generated recognized specific E1 forms (E1-114, E1-90 and E1-67 with anti-gNTE1; and E1-47 with anti-gE1CT)
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The murine subfamily members including and have been identif
2020-09-23
The murine subfamily members including , , , and have been identified and their encoded proteins showed deubiquitinating enzymatic activity , , , . It has been demonstrated that is an immediate-early gene induced by IL-3 in B-lymphocytes and is an IL-2 specific immediate-early gene in T-lymphocytes
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For this reason we hypothesized that the DHFR gene could
2020-09-22
For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693. The variant allele A at this marker seems to reduce the risk of C
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br Introduction The allergic response is a complex process
2020-09-22
Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological
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Next we evaluated the therapeutic potential
2020-09-22
Next, we evaluated the therapeutic potential of compound () using the mouse model of collagen-induced arthritis (CIA model), which is the pathological model for RA. Consequently, oral once-daily dosing of 3 mg/kg reduced the overall progression of the clinical score, including inflammation and bone
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This work is inspired by the
2020-09-22
This work is inspired by the systematic work of Coutinho and co-workers, who obtained several very useful experimental data, which will be also used in our work, and applied the CPA equation of state for the modeling of systems relevant to the production of biodiesel [8], [9], [10], [11], [12], [13]
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Rosiglitazone Neuropsychological studies of adults with prob
2020-09-22
Neuropsychological studies of adults with problem gambling indicate impairments in many cognitive areas including inhibition, working memory, decision-making, cognitive flexibility, and executive planning (Ledgerwood et al., 2012, Goudriaan et al., 2006). Dopamine is a neurotransmitter that regulate
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The results of physical parameters of the prepared samples a
2020-09-22
The results of physical parameters of the prepared samples are summarized in Table 2. The equivalent diameter ranged from 1.09 to 1.14 mm, which is within the required size distribution of 0.8–1.25 mm. A slight increase in size is probably caused by increasing the thickness of the second coat. To d
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br Conflict of interest br
2020-09-22
Conflict of interest Acknowledgements This work was partially supported by University of Cagliari. Introduction Organophosphorous pesticides (OPs) are wildly used in the world due to high efficiency, broad spectrum and low residue, which in turn results in environmental pollution and adver
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Many processes can lead to changes in soil P pools
2020-09-22
Many processes can lead to changes in soil P pools over time. Plant-available P (when measured as DGT P) decreased over time for the INORG-P treatment (Fig. 1a). Orthophosphate can be stabilised with cations such as calcium to produce insoluble phosphates, reducing plant-available P (Bünemann et al.
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