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The excitatory amino acid L glutamate or glutamate mediates
2021-01-23
The excitatory amino Bezafibrate L-glutamate or glutamate mediates most of the excitatory neurotransmission within the mammalian central nervous system (CNS) and has been implicated in numerous peripheral nervous system (PNS) pathways. The excitatory amino acids, including glutamate, are of great p
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Regarding the mechanism of action of CRF
2021-01-23
Regarding the mechanism of action of CRF, several studies have shown that low doses of CRF may preferentially activate CRF1 receptors in glutamatergic projection neurons, serotoninergic neurons or glutamatergic collaterals in the medial prefrontal cortex (Vertes, 2004). Indeed, prosencephalic inacti
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pleasant dream Also important in binding of E to the ER is
2021-01-23
Also important in binding of E2 to the ER is the hydroxyl on the D ring, which has a stabilizing contact with His-524 in ERα (Fig. 7) and with His-475 in ERβ (Fig. S1) [8,9,36,37]. The spatial relationship of the functional groups on the A and D rings on E2 has been used to develop chemicals contai
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In this work we fabricated a
2021-01-23
In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic CAL101 copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR efficiently,
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OxLDL down regulates eNOS and up regulates iNOS thereby
2021-01-23
OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial Bax inhibitor peptide V5 [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNO
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br Conflict of interest statement br Introduction
2021-01-23
Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle
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br Acknowledgments br Introduction Inflammation is the prote
2021-01-23
Acknowledgments Introduction Inflammation is the protective reaction of the body to infection, injury, or irritation with the aim to remove harmful stimuli such as pathogens, damaged cells, or allergic irritants and to initiate the healing process. Inflammatory abnormalities play a crucial rol
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If the factors needed for A NHEJ are
2021-01-22
If the factors needed for A-NHEJ are not completely defined and the A-NHEJ reaction mechanism nebulous, it is also fair to say that the biological role(s) of A-NHEJ is even more poorly understood. Most of the current interest in A-NHEJ, however, stems from its implicated use in the chromosomal trans
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Of note BRQ and LFM are two
2021-01-22
Of note, BRQ and LFM are two well-known immunosuppressive agents (Batt, 1999). As for LFM, it was reported as immunosuppressive therapy for bone marrow (Avery et al., 2004) and renal (Chon and Josephson, 2011) transplantation. Accumulating evidence indicated that organ transplant patients irrelevant
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ON-01910 The overall poor outcomes in
2021-01-22
The overall poor outcomes in ESCC are thought because of a combination of late diagnosis, aggressiveness of the disease, and a lack of effective treatment strategies for systemic disease. Several molecular pathways, such as epidermal growth factor receptor, vascular endothelial growth factor, and p5
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Some studies have demonstrated that
2021-01-22
Some studies have demonstrated that BMSCs can provide several trophic and growth factors that play important roles in cell survival, angiogenesis, and BMSC differentiation, but not cell replacement (Peled et al., 1999, Shen et al., 2007, Ji et al., 2004). This paracrine effect of BMSCs is a potentia
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Pahlavanzadeh and Fakouri Baygi employed PC SAFT EoS to
2021-01-22
Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the 20b of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that the AAD was achieved equal to 36%
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In conclusion the results obtained in this study and
2021-01-22
In conclusion, the results obtained in this study and those recently reported by our group (Abdel-Samad et al., 2012) clearly indicate that a dialogue indeed exists between the systems of NPY and ET-1 at the level of human endocardial endothelial cells, since these cells, whether isolated from the r
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Tibolone is also efficacious on bone
2021-01-22
Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a
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Fisetin tetrahydroxyflavone is a flavonol present in
2021-01-22
Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a flavonol present in several fruits and vegetables such as grape, persimmon, strawberry, apple, and onion at concentrations rangeing from 2 to 160 μg/g. Fisetin is a well–known bioflavonoid with remarkable biological effects including chemopreventive/chemo
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