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br The role of TNFs and AD The
2021-03-24
The role of TNFs and AD The TNF superfamily includes 19 members that can bind 29 different receptors [56, 57]; the 19 members are Lta, TNF-α, lymphotoxin-β (LTβ), OX40L, TNF associated activation protein (TRAP, also named CD40L or gp39), factor associated suicide ligand (FasL), CD70, CD153, 4-1BB
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br Cytokines and NK cells br Combined
2021-03-24
Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK Lithium Citrate have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and ef
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br Rationale Recently we have shown that the nasal
2021-03-24
Rationale Recently we have shown that the nasal CysLT2 receptor localized exclusively in blood vessels and the expression level of the CysLT2 receptor in patients with nasal allergy was higher than that in patients with non-allergic rhinitis (Shirasaki et al. Allergol Int 2013). We hypothesized t
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In this study it was noted that two out
2021-03-24
In this study, it was noted that two out of five E. crassus CYPs (CYP5681A1 and CYP5682A1) had no intron, and 3 others had one intron at different positions (Fig. 3). Number and length of introns are varied in diverse species. For example, most hypotricha genes characterized so far lack introns (Pre
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Prostaglandins PGs are lipid mediators that exhibit a variet
2021-03-24
Prostaglandins (PGs) are lipid mediators that exhibit a variety of physiological properties by interacting specific G protein-coupled receptors (GPCRs) [10]. PGD2 is synthesized from PGH2 through two distinct PGD synthases; lipocalin-type PGD synthase (L-PGDS) and hematopoietic PGD synthase (H-PGDS)
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br Conflicts of interest br Acknowledgements br Lung cancer
2021-03-24
Conflicts of interest Acknowledgements Lung cancer continues to be the leading cause of cancer deaths in the US and worldwide., Non–small-cell lung cancer (NSCLC) remains the predominant form of lung cancer (approximately 85%)., With some improvements in surgical techniques and combined ther
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The evaluation of internal exposure in workers with
2021-03-23
The evaluation of internal exposure in workers with omethoate is challenging. Unfortunately, OPs are metabolized and excreted quickly in the urine usually within 24–48 h of exposure, and the variation in metabolic rates exists. Many factors influence daily urinary output, such as salt intake, urea a
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br Conflict of interest br Supplementary methods
2021-03-23
Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F
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Therefore HNE is an attractive therapeutic target and the
2021-03-23
Therefore, HNE is an attractive therapeutic target and the design of new HNE inhibitors is a demanding field that has been extensively investigated in order to provide inhibitors with new molecular architectures, including the potent oxo-β-lactam class [14]. In the present work, a coumarin-based oxo
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All known vertebrate TRIMs are categorized in
2021-03-23
All known vertebrate TRIMs are categorized in 11 distinct subclasses depending on the types of domains present at their carboxyl-terminals (Fig. 3) [29], [35]. Beyond conserved N-terminal domains, it is the C-terminal that provides specificity of interactions with other proteins. The subclass IV for
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The data from the Sur lab
2021-03-23
The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty HATU synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstream Stimulatory
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One of the most frequent gene
2021-03-23
One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are R547 regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respectively, have
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van Linden et al developed a comprehensive guide
2021-03-23
van Linden et al. developed a comprehensive guide that describes drug and ligand binding to more than 1200 human and mouse protein kinase domains [77]. Their KLIFS (kinase–ligand interaction fingerprint and structure) directory includes an alignment of 85 potential ligand binding-site residues occur
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Apart from neutrophil mediated inflammation
2021-03-23
Apart from neutrophil-mediated inflammation, the production of pro-inflammatory cytokines and chemokines from PGD2/CRTH2 activated macrophages could further aggravate LPS-induced lung injury (Eguchi et al., 2011; Jandl et al., 2016). Interestingly, genetic ablation of CRTH2 diminishes the TNF-α prod
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Kumar et al studied Umbelliferone D galactopyranoside UFG
2021-03-22
Kumar et al. studied Umbelliferone β-D-galactopyranoside (UFG) (benzopyrone), found in many plants exhibiting numerous pharmacological actions. The results of the study showed that UFG in a dose of 10, 20 or 40mgkg-1 per day, helps to prevent paw edema and arthritic score development for arthritis i
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