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br Experimental Procedures br Author Contributions br Acknow
2021-04-14
Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s
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Fusion genes are formed as the
2021-04-14
Fusion genes are formed as the result of either structural chromosomal rearrangement including, primarily, translocation, inversion, amplification and deletion, or non-structural aberrations caused by cis- and trans-splicing or transcriptional read-through. Such events are known to play important ro
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br Activity based probes br Characterization
2021-04-13
Activity-based probes Characterization of coronavirus-encoded DUBs with activity-based probes To study the activity of specific DUBs, investigators frequently take advantage of the ~10kDa (monoUb or Ubl ABP) or ~20kDa (DiUb ABP) increase in MW on probe labeling. SDS-PAGE analysis or blotting f
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Another mechanism underlying on the toxicity of dopaminergic
2021-04-13
Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine Pepstatin A mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxidation to quinon
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Both meiotic COs and NCOs require DNA synthesis
2021-04-13
Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε
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We elucidated that the ten DGK isozymes have
2021-04-13
We elucidated that the ten DGK isozymes have different relative 1-MGK and 2-MGK activities vs DGK activity under the same conditions. However, because the octylglucoside-mixed micellar assay was developed for DGK, it is not known whether the DGKs exhibit maximum 1-MGK and 2-MGK activities in this as
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Electron transport via DHODH activity
2021-04-13
Electron transport via DHODH activity will allow the generation of mitochondrial ROS without the consumption of α-ketoglutarate or NADH. Glutamine-dependent flux through the TCA cycle and oxidative phosphorylation can also enable generation of mitochondrial ROS (Weinberg et al., 2010). The latter pr
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WS 3 DGAT is specifically responsible for endogenous synthes
2021-04-13
DGAT2 is specifically responsible for endogenous synthesis of TAGs which are then packed into cytosolic LDs in the cytosol for storage and luminal apolipoprotein B (apoB)-containing LDs in the ER lumen destined for VLDL secretion [122,127]. DGAT2 can also synthesize TAG using exogenous FAs and suppo
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It is now widely known that blockade of CysLT receptors
2021-04-13
It is now widely known that blockade of CysLT1 receptors strongly inhibits antigen-induced bronchial contractions in specimens isolated from non-asthma subjects. However, this blockade is not complete as shown in the present study and in other literature.4, 15, 16 The results of the current study su
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CRF and urocortin produce marked effects on
2021-04-13
CRF and urocortin 1 produce marked effects on the AM1241 synthesis when administered both i.v. or directly into the CNS (Parkes et al., 2001). Systemic i.v administration of CRF and urocortin 1 cause a marked and long-lasting reduction in mean arterial blood pressure in rats Briscoe et al., 2000, L
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Torin1 br Discussion This study characterized
2021-04-13
Discussion This study characterized longitudinal changes of cholinesterase and PON1 enzyme activities in greenhouse workers over two periods of a crop season with different levels of pesticide exposure. Although study participants were not exposed to OP insecticides, because they worked under int
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The highest concentrations from several tens
2021-04-13
The highest concentrations (from several tens to often hundreds or thousands ng/L) are reported in animal farm flush water, and associated runoffs and lagoons in China and in the U.S. Lower concentrations are reported in WWTP influents and effluents. In WWTP influent waters DRO, LNG, NET and PRG hav
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Of all ES cases approximately
2021-04-12
Of all ES cases, approximately 26–28% are metastatic diseases at diagnosis with the remainder being localized disease [14]. Instituting a systemic chemotherapy regimen in combination with surgery and/or radiotherapy has significantly increased the survival of patients with localized disease. The 5-y
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In rodents Wang et al Wang
2021-04-12
In rodents (Wang et al., 2003, Wang and Tsirka, 2005b, Zhu et al., 2012) and humans (Wang et al., 2011), the major forms of cell death after ICH are necrosis and apoptosis. In the perihematomal region of rodents, the number of necrotic and apoptotic cells peaks at 72h post-ICH (Matsushita et al., 20
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Homologous recombination HR has important roles in the repai
2021-04-12
Homologous recombination (HR) has important roles in the repair of stalled or collapsed DNA replication forks, as well as of DNA double-strand breaks. Among the factors required for HR in human CI 976 australia are RAD51, BRCA1, and BRCA2 (Davies et al., 2001, Sung and Klein, 2006, Xia et al., 2001
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