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Recent studies in our laboratory demonstrated that several h
2022-03-10
Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his
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In this study we also profiled the expression
2022-03-10
In this study, we also profiled the expression of the transporters in wild-type RBL-2H3 cells, RBL-2H3 Sc98 cells, and rat peritoneal mast cells. OCT1 and PMAT were expressed at high levels in both RBL-2H3 Sc98 and RBL-2H3 cells. However, OCT2 and OCT3 were weakly or least detected in RBL-2H3 Sc98 c
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CTGF is an established YAP TAZ target gene
2022-03-10
CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f
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Long non coding RNAs lncRNAs are a class
2022-03-10
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts which are over 200 nucleotides in length and not translated into proteins (Ponting et al., 2009). Recent studies showed that lncRNAs have been identified as crucial regulators of gene expression, chromatin remodeling, and cell cycle (Wahl
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agomelatine br Acknowledgments br Introduction The incidence
2022-03-10
Acknowledgments Introduction The incidence of cholangiocarcinoma (CCA), a malignant tumor found in both intra- and extra-hepatic biliary epithelia [1], has been increased worldwide over the past two decades [2]. The prognosis of CCA patients are generally poor, due to the lack of early detecti
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These to date remain the only two reports of
2022-03-10
These to date remain the only two reports of mutations in GC-C found in humans. Perhaps this once again emphasized the critical requirement of the presence of an optimally functional GC-C in the intestine, since neither its loss, nor its hyperactivity, can be tolerated in humans without severe conse
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Molecular modeling of the sGC H NOX
2022-03-10
Molecular modeling of the sGC H-NOX domain has placed the β1-domain Cys, β1-C78 and β1-C122, close to the heme binding pocket; specifically, the β1-C78 is placed diametrically opposite to β1-H105, the residue responsible for coordinating the heme iron [42,43]. β1-C78 is enclosed in a highly Cy5.5 m
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br Results and discussion br Conclusion In this
2022-03-09
Results and discussion Conclusion In this study the first binding assays based on a nonlabelled reporter ligand addressing GlyT1 are described. Following the concept of MS Binding Assays recently introduced in our group, binding of the well-known GlyT1 inhibitor Org24598 employed as reporter l
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The precise mechanisms of action of PBA are as
2022-03-09
The precise mechanisms of action of 4-PBA are as yet ambiguous. Its capacity as a chemical chaperone has been thoroughly documented for the ABC transporter family in particular (Prulière-Escabasse et al., 2007; Iram and Cole, 2014; Gordo-Gilart et al., 2016; Pomozi et al., 2017). 4-PBA has been clas
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Type diabetes mellitus is characterised by two major feature
2022-03-09
Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta Sodium ascorbate [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due to insulin resistance
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While the apparent complexity of gap junction regulation pre
2022-03-09
While the apparent complexity of gap junction regulation presents challenges, new technologies continue to propel the field forward. Advances in microscopy are increasingly able to capture rapid dynamics at the plasma membrane (e.g., biosensors [67] and lattice light sheet microscopy [100]) and to d
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br BA induced activation of TGR TGR is
2022-03-09
BA-induced activation of TGR5 TGR5 is a membrane-bound G protein-coupled receptor for BAs and its activation is dependent on cAMP formation and further stimulation of protein kinase A [53], [31]. The receptor is expressed in the enterochromaffin cells, smooth muscles, immune cells and more import
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Having shown that some of substitutions Cl
2022-03-09
Having shown that some of substitutions (Cl, CF) at the 2-position of the thiophene improved rat microsomal stability, and polar groups at the 4-position of the aryl ring had a beneficial effect on stability in both human and rat microsomes, we combined these features in a new set of analogs. Methyl
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In analyzed alleles in this
2022-03-09
In 3/11 analyzed Actinomycin D in this study, the c.472C>T missense variant was detected. This variant was previously reported in Malaysian, French, Indian and Pakistani patients (Bhai et al., 2018; Ijaz et al., 2017; Lebigot et al., 2015; Moey et al., 2018; Ngu et al., 2014) who were homozygous an
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The cortical actin filaments are
2022-03-09
The cortical amprenavir filaments are arranged in a network abuting the plasma membrane with a thickness of ∼190nm in living cells, that displays highly dynamic behaviors 15, 16, 17. Technical challenges, however, have hampered investigation of the detailed function dynamic interactions between the
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