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br STAR Methods br Acknowledgments
2022-04-09
STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa
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Here we examined whether complete ablation of GIP production
2022-04-09
Here, we examined whether complete ablation of GIP production could reduce weight gain in the absence of the adipocyte hormone leptin, a condition that results in extreme hyperphagia, obesity, hyperinsulinemia, and insulin resistance, in both mice [24] and humans [25]. We found that Lepob/ob mice be
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α-mangostin So in this study our results firstly demonstrate
2022-04-09
So in this α-mangostin study, our results firstly demonstrated that i.c.v. injection of ghrelin(1–7)-NH2 played a significant role in the modulation of the acute heat pain at the supraspinal level in mice. Our results showed that i.c.v. injection of ghrelin(1–7)-NH2 produced dose- and time- depende
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ARCA Cy3 EGFP While the apparent complexity of
2022-04-09
While the apparent complexity of gap junction regulation presents challenges, new technologies continue to propel the field forward. Advances in microscopy are increasingly able to capture rapid dynamics at the plasma membrane (e.g., biosensors [67] and lattice light sheet microscopy [100]) and to d
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Although several new elements i e microsomes
2022-04-09
Although several new elements (i.e., microsomes and NADPH) were added in E. coli cultures in the current study, the concentration of LacZ gene inducer, IPTG, to stimulate for the maximum production of β-galactosidase enzyme at media pH of 7.0 was observed to be the same as in the previous study (Fig
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Recently accumulated evidence has revealed a
2022-04-09
Recently, accumulated evidence has revealed a close link of FXR to gluconeogenesis. For example, activation of FXR by its agonist GW4064 improved hyperglycemia in db/db mice by repressing gluconeogenesis [15], and FXR agonist CDCA decreased transactivation activity of key gluconeogenic genes by indu
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br RESULTS br DISCUSSION In this study we
2022-04-09
RESULTS DISCUSSION In this study, we found impaired apoptosis in the peripheral blood of RA patients when compared with peripheral blood from normal controls. Our previous studies have shown that the number of CD4 + T MJ33 lithium salt increased while regulatory T (Treg) cells diminished in t
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We characterized the enzyme corresponding to N FPP
2022-04-09
We characterized the enzyme corresponding to N1. FPP was the most effective substrate as allylic diphosphate, and the activities with GPP and DMAPP were 50% and 11% that with FPP, respectively. The analysis of the prenols resulting from the treatment of prenyl diphosphates with cotransporter phospha
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br Materials and methods br
2022-04-09
Materials and methods Results Discussion EZH2 is a subunit of the polycomb repressive complex, which trimethylates lysine 27 on histone 3, a repressive marker for gene expression. EZH2 is important for cancer cell proliferation, migration, and invasion, all of which are associated with canc
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Recent studies in our laboratory
2022-04-09
Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his
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The presence of the H receptor in humans was
2022-04-09
The presence of the H3 receptor in humans was confirmed approximately 25 years ago, and the receptor was successfully cloned in 1999 (Thurmond, 2010). The H3 receptor is unique, as it controls feedback of histamine release, particularly in the central nervous system, where it modulates neurotransmit
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br Tissue Specific Roles for HIF PHD
2022-04-09
Tissue-Specific Roles for HIF/PHD Isoforms Hypoxia signaling pathways are active in almost all mammalian cells, including immune Tovok and tissues such as the epithelium and endothelium. This is of crucial importance when considering the influence of environmental hypoxia in inflammatory conditi
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br Conclusion Infections caused by the P aeruginosa
2022-04-09
Conclusion Infections caused by the P. aeruginosa could not be cured by current antibiotics, making multiple drug resistance of P. aeruginosa an increasing threat for human lives. Looking for a new therapeutic mechanism for infections caused by the P. aeruginosa has become a central issue. There
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In the Hedgehog signaling pathway cholesterol is required to
2022-04-09
In the Hedgehog signaling pathway, cholesterol is required to activate SMO (Cooper et al., 2003), the downstream target of PTCH1. A previous study (Bidet et al., 2011) reported that Patched expression in yeast Ac-IETD-pNA increased extrusion of a fluorescent boron dipyromethanene sterol derivative
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br S proteins and HBV induced autophagy HBV
2022-04-08
S proteins and HBV-induced autophagy HBV surface proteins (S proteins or HBs) are reported to trigger HBV-induced autophagy by inducing ER stress and UPR in host 7-Ethoxyresorufin australia [22]. HBx and HBV-induced autophagy HBx is a multifunctional viral protein. It can regulate virus repl
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