Archives
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Plants Cp are widely distributed in the plant
2020-07-01
Plants Cp are widely distributed in the plant kingdom and are believed to act as virulence/defense factors for both hosts and pathogens. Cp are also found in plants, animals and bacteria and are known to be virulence factors involved in bacterial pathogenicity [29]. Further, Cp are involved in pepti
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In conclusion we demonstrated phenoconversion of CYP A in
2020-07-01
In conclusion, we demonstrated phenoconversion of CYP3A in stable kidney transplant recipients, and that higher plasma indoxyl sulfate concentrations in these subjects may be involved in the phenomenon. The present findings suggest that dose adjustment of drugs metabolized by CYP3A may be needed in
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AS1842856 In conclusion our work provides the preclinical
2020-07-01
In conclusion, our work provides the preclinical evidence showing the potent in vivo efficacy of AT7519 on chemoresistant cancer AS1842856 and its underlying mechanisms of action. Our work supports the biological rationale behind the clinical trials initiated with AT7519, particularly for the treatm
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R co localizes Golgi marker GM Fig
2020-07-01
R co-localizes Golgi marker GM130 (Fig. 5). Our metabolic pulse-chase studies carried out in the presence of CSF-1 exposed the newly synthesized CSF-1R to its ligand, which promoted its rapid degradation. While this was clearly seen in control BMDMs, the mature band of CSF-1R remained intact for the
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Some of the psychoactive actions of nicotine are mediated by
2020-07-01
Some of the psychoactive actions of nicotine are mediated by the nigrostriatal and mesolimbic pathways (Di Chiara, 2000, Di Chiara et al., 2004). The nigrostriatal pathway originates in the dopaminergic neurons located in the substantia nigra and terminates in the putamen and nucleus caudatus which
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Liver metabolic programming begins in utero Aiming
2020-07-01
Liver metabolic programming begins in utero. Aiming to find a reason for the decreased lipid catabolism enzyme expression observed in fetuses and offspring from SFD rats, we studied the effect of leptin on liver catabolism in fetuses from control and SFD rats. Livers from control fetuses responded t
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A recent report has shown that C elegans
2020-07-01
A recent report has shown that C. elegans homozygous for a point mutation within the HORMA domain of HTP-1 (M127K), which disrupts its association with chromosome axes, displayed an extended zone of PLK-2 localization to PCs in response to asynapsis (Silva et al., 2014), which, as we show here, is a
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Selective inhibitor of phosphodiesterase type PDE I is
2020-07-01
Selective inhibitor of phosphodiesterase type 5 (PDE5I) is commonly used for ED treatment. PDE5I exhibits its vasodilatory effect by inhibiting the degradation of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle and allows increased blood flow for penile tumescence. Udenafil (D
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UVRAG is a mammalian ortholog of yeast Vps and a
2020-07-01
UVRAG is a mammalian ortholog of yeast Vps38 and a promoter of autophagy [51,60,61]. It forms distinct complexes with BECN1 (mammalian ortholog of yeast Vps30/Atg6) and the class III phosphatidylinositol 3-kinase (whose catalytic subunit [PIK3C3] is the mammalian ortholog of yeast Vps34) and contrib
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Another important new result that has expanded the range
2020-07-01
Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f
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The majority of serpins inhibit serine proteases but
2020-07-01
The majority of serpins inhibit serine proteases, but serpins that inhibit caspases or papain-like cysteine proteases have also been identified [4], [5]. Inhibitory serpins are ‘suicide’ or ‘single use’ inhibitors that use a unique conformational change to inhibit proteases. This conformational tran
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Our studies approached this problem using integrative omics
2020-07-01
Our studies approached this problem using integrative -omics analysis of human NK-ieILC1s from distinct microenvironments and functional subsets, including helper and adaptive phenotypes. At both the transcriptional and epigenetic levels, we find that the adaptive subset, CD57+ cytotoxic NK cells, s
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phosphocreatine Consistent with our previous study Gao et al
2020-07-01
Consistent with our previous study (Gao et al., 2018b; Wu et al., 2018), we found that TCB-2 disrupted both pup preference and home-cage maternal behavior. Based on the findings that 4-h pup phosphocreatine (a technique presumably increases maternal motivation) failed to attenuate the TCB-2-induced
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The DNA damage response DDR is a cellular mechanism
2020-07-01
The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as Cytarabine regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recogn
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br Acknowledgements br Introductio http www apexbt
2020-07-01
Acknowledgements Introduction TB is also widely prescribed as a stain to identify proteoglycans and glycosaminoglycans (GAGs) in agarose gel electrophoresis (Dietrich and Dietrich, 1976; Coulson-Thomas et al., 2015). In addition, as adjunct to a photodynamic antimicrobial chemotherapy assay, T