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Actin is capable of polymerizing spontaneously
2023-08-17
Actin is capable of polymerizing spontaneously. However, this process is relatively slow and kinetically unfavorable in cells. Formation of Colistin Methanesulfonate sodium salt dimers and trimers, which can easily disassemble due to their instability, is a rate-determining step in actin polymeriza
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ACK has been clearly implicated in
2023-08-17
ACK1 has been clearly implicated in cancer progression in recent years. A strong correlation between ACK1 gene copy number, protein level and activity have been demonstrated in tumors of different tissue types (Mahajan et al., 2007; van der Horst et al., 2005; Wang et al., 2006). Our western blot an
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br The complementary role of chaperone mediated autophagy
2023-08-17
The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa
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br Conclusion In summary screening a small compound library
2023-08-17
Conclusion In summary, screening a small compound library based on the 3-aminopyridin-2-one motif in a target-blind manner against a 26-kinase panel, representative of the kinome, identified hits that possess good activity and excellent ligand efficiency against MPS1, Aurora A and Aurora B. The b
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It is increasingly evident that
2023-08-17
It is increasingly evident that many metabolic genes are associated with cancer progression of various tumor cells, including NSCLC. In particular, GLUT1 overexpression has been reported in NSCLC, and correlations between GLUT1 expression and a number of clinical parameters such as gender, smoking s
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Knowledge about adipose tissue has
2023-08-17
Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to
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NO is an important mediator for maintaining bone integrity s
2023-08-17
NO is an important mediator for maintaining bone integrity since it plays a role in the bone remodeling process. It was shown that mechanical strain and shear stress induce NO synthesis in osteoblasts and osteocytes (van't Hof & Stuart, 2001). It was reported that mechanical loading influences its a
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br Mechanism of action In general the main
2023-08-16
Mechanism of action In general, the main targets for antifungal drug development are cell wall polymer (glucans, chitin, mannoproteins), cell membrane (especially ergosterol) biosynthesis, DNA and protein synthesis (topoisomerases, nucleases, elongation factors and myristoylation), and signal tra
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br Concluding Remarks and Future Perspectives The collective
2023-08-16
Concluding Remarks and Future Perspectives The collective evidence from studies detailing the functions of AMPK in the neuromuscular system, combined with those in DMD, SMA, and DM1 surveyed in the present review, strongly suggests that AMPK is a central mediator of neuromuscular determination, m
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br Material and methods br Results br Discussion Aminopeptid
2023-08-16
Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors
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In a recent series of studies from our laboratory to
2023-08-16
In a recent series of studies from our laboratory, to characterize the contractile systems within the rat thymidylate synthase wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist
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It has been reported that HT R involves in type
2023-08-16
It has been reported that 5-HT2R involves in type 2 diabetes mellitus and 5-HT-induced IR [22,23]. The present study also demonstrated that it is 5-HT2R rather than other 5-HT receptors, including 5-HT1BR and 5-HT7R, in the liver that mediates HFD-induced abnormality of hepatic lipid metabolism, and
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br Effective therapeutic window of
2023-08-16
Effective therapeutic window of AR actions on ROP Retinal vasculature undergoes critical developmental changes postnatally: from P7 onward the superficial Anhydrotetracycline hydrochloride start sprouting vertically in retina to form first the deep then the intermediated vascular plexus in the re
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br Actin cytoskeleton in protrusion Pushing force driving
2023-08-16
Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing 4112 filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lamellipodi
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On another hand pyrazoles are widely found
2023-08-16
On another hand, pyrazoles, are widely found as the core structure in a large variety of compounds of great biological and pharmaceutical value exhibiting anti-HCV [11], antitumor [12], cytotoxic[13], and antioxidant activities [14]. Finally, 1,2,3-triazoles have attracted the interest of medicinal
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