Protein phosphorylation is an important posttranslational me

Protein phosphorylation is an important posttranslational mechanism for the regulation of distribution, trafficking, and function of modified proteins (Wang et al., 2014). GluA1 phosphorylation at S845 also has functional consequences (Lu and Roche, 2012). For instance, S845 phosphorylation drove trafficking of GluA1/AMPA receptors onto extrasynaptic sites (Chao et al., 2002, Mangiawacchi and Wolf, 2004, Man et al., 2007), facilitating the subsequent Clofibric Acid synthesis of these receptors into synapses (Estaban et al., 2003; Sun et al., 2005, Gao et al., 2006, Oh et al., 2006, 2008). The elevated synaptic delivery of GluA1 may result in potentiating the peak current of AMPA receptor channels (Roche et al., 1996). In sum, the regulatory role of M4 receptors in striatal S845 phosphorylation revealed in this study paves the way for future studies to determine an underlying molecular mechanism for modulating AMPA receptors in response to changing synaptic input in striatal neurons.