br Conclusion These are exciting

Conclusion These are exciting times in EAAT research. The discovery and use of the GltPh and GltTk transporters as model systems for EAATs has provided detailed understanding of structure–function aspects of the transporters. Moreover, recent studies into the physiological functions of the transporters have confirmed their considerable therapeutic potential. In view of this, the present shortage of ligands suited to explore this Gap19 potential is highly unfortunate, and we hope that the coming years will see the discovery of an arsenal of selective pharmacological tool compounds for these fascinating transporters.
Conflict of interest statement
References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as:
Acknowledgements The authors thank the Novo Nordisk Foundation and the Danish Medical Research Council for financial support.