• Our results indirectly support the combination of resveratro

  2019-11-07

  

  Our results indirectly support the combination of resveratrol and hesperatin treatment for PDN, as this induces GLO1 activity in patients (Xue et al., 2016), as well as metformin, an FDA-approved anti-diabetic treatment, which acts as an MG scavenger to reduce MG levels in type 2 diabetic patients (

• The reaction of chitosan with DVS should take place primaril

  2019-11-07

  

  The reaction of chitosan with DVS should take place primarily through a nucleophilic attack of the vinyl sulfone groups to the amino groups in chitosan [39,50], although its hydroxyl groups can also be involved, as it happens when using agarose [35]. These reactions create very stable secondary amin

• The prospects of the use of

  2019-11-07

  

  The prospects of the use of this novel approach for the selective local thermo-activation of enzymes include biomedical and biotechnological applications. As NPs could be engineered to gain access to sars-cov through the endosomal compartment [47] or through non-endocytotic pathways [48], [49], [50

• br Materials and methods br Results and discussion br

  2019-11-07

  

  Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic Aprotinin is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacteria such as Lactobacillus plant

• Judging from the densitometric analysis of the Western blots

  2019-11-07

  

  Judging from the densitometric analysis of the Western blots, CYP2E1 protein was expressed, although at very low levels, by PT cells. This corresponds to previous observations [10], showing that CYP2E1 was expressed in the PT, although expression was higher in the distal tubule. Testosterone 6β-hyd

• Contrary to the downregulation of S PR family GPCRs

  2019-11-07

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic Erismodegib receptor (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disease

• Previous in vitro and in vivo studies have shown

  2019-11-07

  

  Previous in vitro and in vivo studies have shown the potent ability of toll-like receptor (TLR) ligands and type I interferon (IFN) signaling to induce CH25H in macrophages and DCs following exposure to innate immune stimuli (Bauman et al., 2009; Diczfalusy et al., 2009; Park and Scott, 2010; Zou et

• Main Text Post translational modifications by ubiquitin Ub a

  2019-11-07

  

  Main Text Post-translational modifications by ubiquitin (Ub) and ubiquitin-like proteins (Ubl) regulate a diverse array of cellular and physiological processes including protein degradation, localization, and activation. While ubiquitination has primary responsibility for targeting substrates for p

• br Materials and methods br Results br Discussion UPP compon

  2019-11-07

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important RO4987655 receptor of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylati

• Gemcitabine Alpha SYN has no direct

  2019-11-07

  

  Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between

• In vitro study indicated the cell death

  2019-11-07

  

  In vitro study indicated the cell death of hippocampal neurons was mediated by DAPK1 following ceramide-3 treatment (Pelled et al., 2002). the same study showed that DAPK1-deficient mice treated by acyl ceramide exhibit a less sensitivity to apoptosis, this proposed that DAPK1 plays a central role i

• Due to its several industrial applications the recombinant

  2019-11-07

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian Anisodamine (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 200

• In human neuroblastoma SH SY

  2019-11-07

  

  In human neuroblastoma SH-SY5Y Nitrotetrazolium Blue chloride and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by direc

• In general the DNMT encompass three different

  2019-11-06

  

  In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated

• It is well established that p maintains genomic integrity

  2019-11-06

  

  It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause synthase arrest and to repair cellular damage. There is growing evid

16419 records 961/1095 page Previous Next First page 上5页 961962963964965 下5页 Last page