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Cytokines are small secreted proteins that mediate and
2020-01-02
Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus. Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or diff
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kras-pdeδ inhibitor Air trapping at the small
2020-01-02
Air-trapping at the small airways is related to severe kras-pdeδ inhibitor (Bjermer, 2014), and acute exacerbation (Mahut et al., 2010). Although asthma patients are generally treated with inhaled corticosteroid (ICS) or with ICS and long-acting β2 agonist (LABA), the efficacy of such treatment dep
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However recent studies revealed that the function of Crm mig
2020-01-02
However, recent studies revealed that the function of Crm1 might not only limit to nucleocytoplasmic transport, but also be involved in regulation of centrosome duplication. As the major microtubule organizing centers in animal cells, centrosomes play a significant role in cell cycle, spindle format
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br Acknowledgements This work was supported by a grant from
2020-01-02
Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem
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UK-5099 It is also meaningful to discuss whether VSOR Cl
2020-01-02
It is also meaningful to discuss whether VSOR Cl− channel-induced apoptosis is correlated with the ER pathway. Thus, in this study, we sought to clarify the intrinsic relationship between VSOR Cl− channels and the level of ER stress-related proteins. The research results are as follows: the expressi
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Chlorogenic acid br Experimental Procedures br Author Contri
2019-12-31
Experimental Procedures Author Contributions Acknowledgments Introduction Oxysterols came to prominence in the late 1970\'s with the oxysterol hypothesis which proposed that the suppressive effect of cholesterol on its own synthesis is mediated through oxysterols not by cholesterol itsel
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Some mechanistic experiments performed in
2019-12-31
Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects l-ascorbic acid from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This e
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br Conflict of interest statement
2019-12-31
Conflict of interest statement Acknowledgement The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc) Introduction Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like
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br Materials and methods br Results br Discussion
2019-12-31
Materials and methods Results Discussion The oestrogen agonist properties and androgen antagonist activities of parabens have been well documented by a variety of in vitro and in vivo assay systems over the past decade (Chen et al., 2007, Darbre and Harvey, 2008, Golden et al., 2005). To th
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Table presents results for estimation of Eq using ACTR
2019-12-30
Table 4 presents results for estimation of Eq. (1) using ACTR and SUWE to compare the incidence of attempting the exam between programs. We find alumni are more likely to attempt the exam if they β-Pompilidotoxin do not hold another professional certification, have worked for an accounting firm, hav
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br Methods and materials br
2019-12-30
Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic pkc inhibitor to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in
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br Materials and methods br Results br Discussion
2019-12-30
Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te
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In conclusion our data represents a step
2019-12-30
In conclusion, our data represents a step forward in terms of clarifying the role of I/D polymorphism of ACE and VNTR polymorphism of eNOS and G1793A, C677T and A1298C polymorphism of MTHFR in pathophysiology of psoriasis in Pakistani patients. It will help in better understanding of the disease pro
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ack1 inhibitor A growing body of data indicates that endothe
2019-12-30
A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream ack1 inhibitor molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in the conce
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br Acknowledgement We acknowledge for funding support from M
2019-12-30
Acknowledgement We acknowledge for funding support from Maryada Foundation, a DoD/Army Contract No. W911NF-06-1-0095, and National Institutes of Health through the New England Center of Excellence for Biodefense (Grant AI057159-01). Introduction The Gram-negative bacterium Lysobacter sp. XL1
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