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br Materials and methods br Results br
2020-01-10
Materials and methods Results Discussion Schistosome cercarial elastase secreted from the acetabular glands of cercariae is recognized to play a critical role in mammalian host skin penetration upon infection. The present study extends the understanding of biochemical and immunological prop
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Cynomolgus HGF / Hepatocyte Growth Factor Protein Enzyme mi
2020-01-09
Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a
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In summary we investigated the fluoride sensitivity
2020-01-09
In summary, we investigated the fluoride sensitivity of different S. mutans strains in terms of enolase activity. Lower enolase activity was not always associated with lower S. mutans growth in cultures with NaF. Gene analysis showed that UA130 and NCH105 both have enolase point mutations. Unique am
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Our results demonstrated that ET a Wnt ligand
2020-01-09
Our results demonstrated that ET-1, a Wnt ligand, stimulated the Wnt/β-catenin signaling pathway. First, ET-1/ETRA binds to Frizzled family cell-surface receptors, resulting in the activation of Dvl1, a Dishevelled (DSH) family protein. Next, activated DSH inhibits the Axin, GSK-3β, and APC protein
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br Introduction Cancer related inflammation is associated wi
2020-01-09
Introduction Cancer related inflammation is associated with poor prognosis and reduced survival in numerous human malignancies. Expansion of myeloid derived immune thyroid hormone receptor in response to tumor-secreted factors largely contributes to the heightened systemic and intra-tumoral infl
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br Introduction br Sphingolipid metabolism Sphingolipids are
2020-01-09
Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and AACOCF3 with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed by multiple pat
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br Use of recombinant collagen to study
2020-01-09
Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to
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Collagen alignment can contribute to tissue stiffening Malik
2020-01-09
Collagen alignment can contribute to tissue stiffening (Malik et al., 2015, Paszek et al., 2005), and ECM stiffness in turn is a powerful activator of integrin function (Levental et al., 2009). These findings highlight the contribution of the mechanical properties of the ECM to signal transduction.
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Cytochrome P CYP enzymes plays an essential role in pharmaco
2020-01-09
Cytochrome P450 (CYP-450) enzymes plays an essential role in pharmacology of drugs and toxicology of xenobiotics. Inhibition of these enzymes may lead to increase plasma levels of a concomitantly administered drug (Lee et al., 2013). It may prolong or reduce the pharmacological effects and increase
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br Conclusions br Introduction Today just as
2020-01-09
Conclusions Introduction Today – just as for the past 50 years – the most commonly used repellent in the world is DEET (Fradin, 1998; Pickett et al., 2008). The active ingredient, N,N-Diethyl-m-toluamide, is an oily synthetic substance applied topically to the skin in order to alter the host f
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br Conclusions and future perspectives
2020-01-09
Conclusions and future perspectives It is now evident that selective ETA or nonselective endothelin receptor antagonism provides therapeutic potentials against a variety of cardiovascular diseases such as hypertension, PAH, and diabetic microvascular dysfunction (Fig. 1). However, PAH is currentl
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Although DP technologies are convenient for
2020-01-09
Although 3DP technologies are convenient for users to manufacture devices automatically, the printing materials are inevitably limited by the manufacturers of 3D printers. Strategies are increasingly being developed to functionalize the raw printing materials or their printed devices with other phys
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A previous report showed that the transfer
2020-01-08
A previous report showed that the transfer of the CSF1 gene into tumor Rimonabant induced TAM infiltration into syngeneic BALB/c mice. High expressions of CSF-1 and CSF-1R in tumor and stromal cells and a high TAM density are known to be correlated with poor prognoses in many cancer types. CSF-1 pro
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To our knowledge immunohistochemical analysis for proGRP was
2020-01-08
To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor ras inhibitor were positive for proGRP in one case [9]. Yamaguchi et al. also showed that tumor cells in two patients of ES/PNET with elevated serum p
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br Oxidoreductase like MEM for prodrug activation br Future
2020-01-08
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2
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