• br The major regulator of

  2021-08-18

  

  The major regulator of radiation sensitivity Tumor cell resistance to radiation is a big issue for radiation therapy, and a major concern of radiation oncologist. Understanding the regulation mechanism of radiation sensitivity is still a research hotspot. Increased sensitivity to ionizing radiati

• An AmDH is engineered by mutating two conserved amino acid

  2021-08-18

  

  An AmDH is engineered by mutating two conserved amino HKI-272 residues in the active site of an amino acid dehydrogenase (AADH). Starting from the leucine dehydrogenase (LeuDH) from Bacillus stearothermophilus, substituting a serine and leucine at the K68 and N261 positions, respectively, resulted

• br Introduction Lycium barbarum also known as wolfberry belo

  2021-08-17

  

  Introduction Lycium barbarum, also known as wolfberry, belongs to the plant family Solanaceae. Red-coloured fruits of L. barbarum are used as traditional Chinese herbal medicine to promote health and longevity and as a food supplement for thousands of years [1]. They possess many biological activ

• Following mutagenesis of the glucarpidase

  2021-08-17

  

  Following mutagenesis of the glucarpidase gene of Pseudomonas sp. strain RS-16 [30], approximately 73% of the clones retained enzyme activity, as indicated by the clear zones and yellow precipitate surrounding their colonies. However, there were very few that had ‘halos’ around colonies that were da

• sphingosine-1-phosphate As mentioned above disruption of Tgi

  2021-08-17

  

  As mentioned above, disruption of Tgif1 in mice is associated with dyslipidemia, and here we investigate the effects of overexpression of TGIF1 on expression of the Npc1l1 gene and markers of intestinal cholesterol absorption. Materials and methods Results Discussion In this study, we soug

• br Introduction Myotonic dystrophy dystrophia myotonica

  2021-08-17

  

  Introduction Myotonic dystrophy (dystrophia myotonica, DM) is an autosomal dominant disorder and the most common form of inherited muscular dystrophy in adults [1]. DM is characterised by a wide range of symptoms, including myotonia, progressive muscle loss, cataracts, cardiac conduction defects,

• Although it remains an unsettled issue evidence favors that

  2021-08-17

  

  Although it remains an unsettled issue, evidence favors that the endothelin ETA Dihydro-β-erythroidine hydrobromide receptor may play a more important pathological role. While both endothelin ETA and ETB receptors are found in most tissues, endothelin ETA receptor is the predominant receptor respon

• Several large scale clinical studies have set

  2021-08-17

  

  Several large-scale clinical studies have set out with the common goal to further understand the cognitive impact of menopause and hormone therapies taken by women (Gleason et al., 2015, Greendale et al., 2011, Karlamangla et al., 2017, Rapp et al., 2003, Shumaker et al., 2003). Only one human study

• Then the mechanisms responsible for BPA

  2021-08-17

  

  Then the mechanisms responsible for BPA induced up regulation of ERRγ were further investigated. Recent studies indicated that Akt and MPAK can modulate the protein levels and transcriptional activities of ERRγ (Heckler et al., 2014, Sun et al., 2014). Previous studies also indicated that BPA can ac

• In a recent report Yoshihara and colleagues used transcripto

  2021-08-17

  

  In a recent report, Yoshihara and colleagues (2016) used transcriptomes derived from freshly isolated islets of 2-week-old neonatal, 6-week-old young adult, or 12-week-old adult mice to interrogate how maturation is regulated to acquire glucose responsiveness. The authors observed that estrogen-rela

• Similarly EGCG restored the mitochondrial

  2021-08-17

  

  Similarly, EGCG restored the mitochondrial energy shortfall in fibroblasts and lymphoblasts of the patients affected by Down syndrome, even so the mechanism of the effect was not clearly known (Valenti et al., 2013). EGCG also stimulated the mitochondrial biogenesis by activation of nuclear respirat

• Therefore HNE is an attractive therapeutic target and the de

  2021-08-17

  

  Therefore, HNE is an attractive therapeutic target and the design of new HNE inhibitors is a demanding field that has been extensively investigated in order to provide inhibitors with new molecular architectures, including the potent oxo-β-lactam class [14]. In the present work, a coumarin-based oxo

• br Results br Discussion The process by which

  2021-08-17

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor GSK2578215A within the GC. The identification here of a distinct subset of GC B cells, CCR6+ LZ

• br Results br Discussion It has been thought

  2021-08-17

  

  Results Discussion It has been thought that commitment to the plasma cell fate begins while Fmoc-Gln(Trt)-OPfp synthesis are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cel

• Since the interaction between the E and

  2021-08-17

  

  Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y

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