• Distribution of Iodine labeled ANP

  2021-12-16

  

  Distribution of 125Iodine-labeled-ANP (125I-ANP) radioactivity on the cell surface, in the intracellular compartments, and in culture medium established a dynamic equilibrium of receptor-mediated 125I-ANP uptake, degradation, and release outside of Thymidine (Fig. 2). A major proportion of internali

• In addition to the role of TGR the

  2021-12-16

  

  In addition to the role of TGR5, the FXR-FGF15/19 axis has been implicated in other aspects of glucose metabolism and metabolic disorders. In humans, both obesity and type 2 diabetes mellitus (T2DM) are associated with lower plasma FGF19 levels [67,68]. A derivative of the naturally occurring FXR ag

• Thyroid hormone triiodothyronine T and its precursor thyroxi

  2021-12-16

  

  Thyroid hormone 3,5,3′-triiodothyronine (T3) and its precursor, thyroxine (T4), are iodinated compounds, which are known to regulate the expression of genes involved in various biological processes, such as development, growth and metabolic control. The iodothyronine deiodinase types I, II and III (

• Histamine functions as a key neurotransmitter

  2021-12-16

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, Leflunomide is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathw

• Introduction Glucose is the most important energy carrier of

  2021-12-16

  

  Introduction Glucose is the most important energy carrier of the brain. Glucose transporter type 1 (Glut1) is located at the blood–brain barrier and assures the energy-independent, facilitative transport of glucose into the brain [1]. Twelve transmembrane segments of the protein and an intracellula

• Here we studied the effects of

  2021-12-16

  

  Here we studied the effects of BZ flurazepam (FZ) at high doses in acute and chronic settings of tolerance and dependence in GluR-A−/− mice (Zamanillo et al., 1999). We used measurements in which the phenomenon of “learning while intoxicated” should play only a minor role in order to find out the si

• Acarbose and voglibose the classic glucosidase

  2021-12-16

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• Administration of a fructose rich diet

  2021-12-16

  

  Administration of a fructose-rich diet to normal rats induces insulin resistance and impaired glucose tolerance or diabetes, depending on treatment duration [23]. We have shown that development of these abnormalities as well as fat deposit in liver, are effectively prevented by co-administration of

• br Pannexins which form channels connecting cells with

  2021-12-16

  

  Pannexins, which form channels connecting AICAR with the extracellular environment, have also been studied in the setting of NASH. When open these channels participate in inflammatory processes. A decrease in lobular inflammation and oxidative stress was observed in mice with pannexin deletion. Ho

• Acetylation of histones by histone acetyltransferases

  2021-12-15

  

  Acetylation of histones by histone acetyltransferases stimulates gene expression by relaxing monensin structure, allowing access of transcription factors to DNA, whereas deacetylation of histones by histone deacetylases promotes chromatin condensation and transcriptional repression. Recent studies d

• The repurposing of well characterized and well tolerated dru

  2021-12-15

  

  The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that

• Hippo pathway proteins could synergistically regulate germ c

  2021-12-15

  

  Hippo pathway proteins could synergistically regulate germ cell development with some specific receptors. Kassab et al. [27] found that epidermal growth factor (EGF) receptor was localized in testicular germ EW-7197 and played important roles in bovine spermatogenesis. Likewise, insulin-like growth

• An isoflavone type secondary metabolite Glabrescione

  2021-12-15

  

  An isoflavone type secondary metabolite, Glabrescione B (GlaB), from Derris glabrescens (Benth.) J.F. Macbr. from the family Fabaceae, was found to possess the capacity to bind the Gli1 zinc finger domain and to further block DNA binding capacity [118]. Pyrvinium, an anthelmintic drug approved by th

• br Competing interests br Funding br Ethical approval br

  2021-12-15

  

  Competing interests Funding Ethical approval Acknowledgement Introduction Hepatitis C is a disease that infects the liver through transmission of the hepatitis C virus (HCV). Because the symptoms of this infection are not pronounced, the infected individuals may not even be aware of t

• Here we report the genomic structure and

  2021-12-15

  

  Here we report the genomic structure and the phylogenetic analysis of testis-specific Ser/Thr kinase haspin gene. Materials and methods Results Discussion The isolation and analysis of haspin genomic DNA showed that haspin was an intron-less gene and localized in an intron of integrin αM29

16765 records 568/1118 page Previous Next First page 上5页 566567568569570 下5页 Last page