• br Materials and methods br Results br Discussion Numerous

  2024-11-13

  

  Materials and methods Results Discussion Numerous studies showed that Na+-K+-ATPase activity and membrane DGAT-1 inhibitor were decreased in cardiac tissue subjected to IR (Belliard et al., 2013; Lee et al., 2013). In return, treatment that alleviated the progress of IR-related myocardial

• br Materials and methods br Results br Discussion Many

  2024-11-13

  

  Materials and methods Results Discussion Many studies investigate the role of 12/15-LOX in cancer cell,23, 24, 25 however we here first found that host 12/15-LOX also plays an important role in metastasis progression. We have demonstrated that 12(S)-HETE increased melanoma cell adhesion to

• Since immunoassays cannot specifically quantify each

  2024-11-12

  

  Since immunoassays cannot specifically quantify each apelin peptide, a more reliable approach, mass spectrometry (MS) has been used recently to quantify and characterize apelin fragments in plasma. Using this technology, Zhen et al. showed that [Pyr-1]-apelin-13 was the major apelin form present in

• br The prevalence of diabetes is increasing globally and

  2024-11-12

  

  The prevalence of diabetes is increasing globally, and the situation is particularly alarming in Asia. The prevalence of diabetes in China has increased dramatically, from around 1% in 1980 to the most recent estimate of 9.7% according to a nationwide survey . Cumulative evidence shows that type 2

• Introduction Inflammasomes are large cytosolic protein compl

  2024-11-12

  

  Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern aldehyde dehydrogenase inhibitor (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) d

• br Endoplasmic reticulum protein ERp binds to

  2024-11-12

  

  Endoplasmic reticulum protein 46 (ERp46) binds to AdipoR1 in HeLa cells ERp46 is localized in the ER and is suggested to act as a chaperone. About 20% of endogenous ERp46 are found at the plasma membrane suggesting that this protein may have additional functions. ERp46 interacts with Capreomycin

• Notably our preliminary results confirmed that fluoxetine SS

  2024-11-12

  

  Notably, our preliminary results confirmed that fluoxetine (SSRIs, 5–10 mg/kg) and duloxetine (SNRIs, 5–10 mg/kg) could not enhance memory function in the novel object recognition or step-down passive avoidance tasks (data not shown). In the present study, we also found that vilazodone showed had no

• It has been suggested that the suppression of LOX could

  2024-11-11

  

  It has been suggested that the suppression of 5-LOX could promote apoptotic signaling pathways in cancers [6]. However, the role of 5-LOX in modulating apoptotic factors and neutrophil activation during ANP has not yet been evaluated. In this study, we aimed to evaluate the expression of 5-LOX in pa

• br Regulation and pharmacology of mPGES mPGES kDa

  2024-11-11

  

  Regulation and pharmacology of mPGES-1 mPGES-1 (16 kDa, 152 amino acids) is a trimeric integral membrane protein of the endoplasmic reticulum with each monomer containing four transmembrane domains (Samuelsson et al., 2007; Sjogren et al., 2013). The three active site cavities are located at the

• Introduction Lysophosphatidic acid LPA is a key serum

  2024-11-11

  

  Introduction Lysophosphatidic 4-ethylphenyl sulfate synthesis (LPA) is a key, serum-borne phospholipid, regulating a number of cellular processes such as proliferation, migration and differentiation through its interaction with G-protein coupled receptors. LPA receptor signaling has been implicated

• We have recently reported a regulatory effect of quercetin o

  2024-11-11

  

  We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the

• It was reported that overexpression of the rat ACL gene

  2024-11-11

  

  It was reported that overexpression of the rat ACL gene in tobacco increased the total ACL activity by 4 fold, which increased the production of fatty acids by 16% [8]. Recently, a 1.7-fold increase of fatty acids and 1.9-fold increase of triacylglycerol (TAG) was observed in Aspergillus oryzae with

• br Conclusion br Acknowledgement This study was supported by

  2024-11-11

  

  Conclusion Acknowledgement This study was supported by NIH/NINDSR01 NS036812-16. Introduction Stroke is the leading cause of disability and the fifth leading cause of death in the United States (Writing Group et al., 2016). On average, every 4 min a human dies of stroke (Lackland et al., 2

• The amino hydroxy methyl isoxazolepropionic acid AMPA recept

  2024-11-11

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic sigma receptor (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche, 2

• br Conclusions The present protocol for localizing

  2024-11-11

  

  Conclusions The present protocol for localizing or “spotting” the site of action of an antioxidant in a micro-heterogeneous medium is based on the differences in its reactivity vis-à-vis the series of amphiphobic TEMPO derivatives 1a–f. Plots of the relative antioxidant effectiveness of a given A

16308 records 53/1088 page Previous Next First page 上5页 5152535455 下5页 Last page