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In the present study cells
2020-05-29
In the present study, cells were exposed to a low level of arsenite and a low cytotoxic concentration of BaP. Thus, γ-H2AX loss correlated with repair of DNA damage in cells co-exposed to arsenite and BaP. These results show that arsenite inhibits repair of BaP-induced DNA damage. In a previous stud
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Our finding that activating DDR variants are a cause of
2020-05-29
Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho
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br Introduction Identification and correct storage of
2020-05-29
Introduction Identification and correct storage of seminal stains are crucial for the investigation of sexual assault cases. Actually, undetected ‘cold’ cases involving sexual assault can be solved decades after investigations analysing DNA from stored evidences [1]. Recently, STR analysis and th
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The commonly used eDNA stains we evaluated
2020-05-29
The commonly used eDNA stains we evaluated were the intercalating dye propidium iodide, the highly sensitive stain PicoGreen commonly used in DNA quantification, the cyanine monomer SYTOX® Green, and the dye 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO) not only sold as a standard for
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Ciprofibrate receptor Sp family protein has been regarded as
2020-05-29
Sp family protein has been regarded as the housekeeping gene and is ubiquitously expressed. Although Sp family expression is regulated with some stimuli [17], [20], the total Sp family protein levels are not changed in most cases, as observed in our present study (Fig. 4). Constitutive binding of th
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Interestingly genome wide association studies
2020-05-29
Interestingly, genome-wide association studies have linked the chromosomal region harboring RDHE2 (SDR16C5) and seven other genes to stature and growth in cattle, humans, and pigs [30], [31], [32], [33], [34], [35], [36], [37], and beak deformity in chickens [38]. The most recent study specifically
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The consistent anti anxiety effects obtained
2020-05-29
The consistent anti-anxiety effects obtained with intra-mPFC injections of CP 376395 strongly suggest a tonic role of CRF at CRF1 receptors located within this limbic Triflurdine area in the modulation of anxiety in the mouse on the EPM. Intra-mPFC injection of CP 376395 led mice to explore the pot
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Data presented herein suggest that competent IL BP productio
2020-05-29
Data presented herein suggest that competent IL-18BP production in epithelial Deoxycholic acid synthesis is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells a
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Resistance to avermectins has been associated
2020-05-28
Resistance to avermectins has been associated with point mutations of GluCls in C. elegans, D. melanogaster, T. urticae and P. xylostella (Dent et al., 2000; Dermauw et al., 2012; Kane et al., 2000; Kwon et al., 2010; Wang et al., 2016a, 2017). Our electrophysiological study found a 8.2-fold reducti
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Although it is well established
2020-05-28
Although it is well established that estrogen and ESR1 mediate numerous reproductive processes, increasing evidence suggests that ESR2 also lays an integral role in reproduction. ESR2 is a mediator in folliculogenesis and may also act by stimulating ovulation and regulating luteinization (Su et al.,
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Quinacrine hydrochloride hydrate Covalent inhibitors are wel
2020-05-28
Covalent inhibitors are well suited for targeting the E1 Quinacrine hydrochloride hydrate of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compound
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br Introduction Cerebral stroke causes an
2020-05-28
Introduction Cerebral stroke causes an efflux of various groups of progenitor and stem cells from bone marrow to bloodstream and the levels of these cells correlate with neurological status of stroke patients (Gójska-Grymajło et al., 2012, 2018). It is thought that paracrine factors produced by t
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The effect of ET activity on
2020-05-28
The effect of ET-1 activity on the development of experimental pulmonary fibrosis has also been examined by other investigators. One study found that repeated administration of Bosentan, an ERA used to treat pulmonary arterial hypertension (PAH), significantly decreased bleomycin-induced pulmonary f
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It is particularly notable that CYP D appears to be
2020-05-28
It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 BTL-105 in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between indiv
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br Asb Proteins and Mitochondrial Function Mitochondria
2020-05-28
Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic jtc motors and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate a plethora of proce